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. 2021 Sep 2;16(1):1286–1298. doi: 10.1515/med-2021-0335

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© 2021 Yi Ou et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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Baicalin ameliorates renal injury by inhibiting the activation of PI3K/Akt/mTOR signaling pathway in DN rats. 30 SD rats are randomly divided into 5 groups (6 rats in each group) which are control group, DN group, 740Y-P group (3.5 mg/kg PI3K activator), Baicalin group (200 mg/kg baicalin), Baicalin + 740Y-P group (200 mg/kg baicalin + 3.5 mg/kg 740Y-PA), with 4 weeks of gavage. (a) qRT-PCR to detect the mRNA expressions of Nephrin, Podocin, and Desmin in the kidney tissues of rats in each group; (b) Western blot to detect the protein expressions of p-PI3K, PI3K, p-Akt, Akt, p-mTOR, and mTOR in the kidney tissues of rats in each group. *p < 0.05 vs DN group; ^& p < 0.05 vs Baicalin group; and ^# p < 0.05 vs DN + 740Y-P group.