Table 3.
Arterial blood gas profiles for ALI patients in the COVID-19 and non-COVID-19 cohorts.
| Normal range | Total (n = 220) | COVID-19 (n = 90) | Non-COVID-19 (n = 130) | p-value | |
|---|---|---|---|---|---|
| ICU panel | |||||
| pH | 7.35–7.45 | 7.30 (7.25–7.33) | 7.31 (7.26–7.34) | 7.30 (7.25–7.32) | 0.103 |
| <7.35 | 192 (87.3%) | 74 (82.2%) | 118 (90.8%) | 0.062 | |
| >7.45 | 11 (5.0%) | 6 (6.7%) | 5 (3.8%) | 0.363 | |
| Base excess, mmol/L | −3–3 | −5.2 (−8.1–1.8) | −5.8 (−9.4–1.5) | −4.5 (−7.3–1.9) | 0.068 |
| < -3 | 128 (58.2%) | 58 (64.4%) | 70 (53.8%) | 0.117 | |
| >3 | 47 (21.4%) | 19 (21.1%) | 28 (21.5%) | 0.939 | |
| [], mmol/L | 22–27 | 20.9 (18.3–25.1) | 19.7 (17.9–23.5) | 22.6 (19.2–25.8) | 0.004 |
| <22 | 121 (55.0%%) | 61 (67.8%) | 60 (46.2%) | 0.002 | |
| >27 | 40 (18.2%) | 14 (15.6%) | 26 (20.0%) | 0.401 | |
| PaO2, mmHg | 80–100 | 62.6 (58.0–66.3) | 60.7 (56.4–65.2) | 62.7 (59.4–67.6) | 0.006 |
| <80 | 206 (93.6%) | 90 (100.0%) | 116 (89.2%) | 0.001 | |
| PaCO2, mmHg | 35–45 | 49.3 (42.5–55.0) | 47.4 (38.9–53.7) | 50.5 (44.9–56.6) | 0.004 |
| <35 | 13 (5.9%) | 10 (11.1%) | 3 (2.3%) | 0.009 | |
| >45 | 147 (66.8%) | 50 (55.6%) | 97 (74.6%) | 0.003 | |
| SO2, % | 95–100 | 92.0 (88.2–94.0) | 90.5 (87.0–93.3) | 92.0 (90.0–94.0) | 0.012 |
| <95 | 186 (84.5%) | 79 (87.8%) | 107 (82.3%) | 0.270 | |
| PaO2/FiO2 | >300 | 217.3 (197.6–247.3) | 218.6 (197.3–253.1) | 211.9 (197.6–239.5) | 0.367 |
| ≤ 300 | 220 (100.0%) | 90 (100.0%) | 130 (100.0%) | ||
| aADO2, mmHg | 0–100 | 90.4 (78.4–107.4) | 92.9 (79.7–108.5) | 89.2 (76.8–105.7) | 0.269 |
| >100 | 78 (35.5%) | 34 (37.8%) | 44 (33.8%) | 0.549 | |
| HbO2,% | 90–95 | 85.5 (80.9–89.3) | 81.5 (76.5–85.5) | 87.3 (84.8–90.4) | <0.0001 |
| <90 | 176 (80.0%) | 83 (92.2%) | 93 (71.5%) | 0.0002 | |
| MetHb, g/dL | 0.2–0.8 | 0.4 (0.3–0.6) | 0.4 (0.3–0.6) | 0.4 (0.3–0.5) | 0.094 |
| <0.2 | 9 (4.1%) | 3 (3.3%) | 6 (4.6%) | 0.741 | |
| tHb, g/dL | 11.5–17.4 | 9.1 (8.2–9.9) | 8.7 (7.5–10.0) | 9.2 (8.3–9.8) | 0.212 |
| <11.5 | 208 (94.5%) | 81 (90.0%) | 127 (97.7%) | 0.017 | |
Actual bicarbonate, []; PaCO2, the partial pressure of carbon dioxide; PaO2, the partial pressure of oxygen; SO2, the oxygen saturation; PaO2/FiO2, the oxygenation index; aADO2, alveolar-arterial oxygen pressure; tHb, the total hemoglobin; HbO2, the oxygenated hemoglobin; MetHb, methemoglobin.