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. 2021 Sep 3;16(9):e0256979. doi: 10.1371/journal.pone.0256979

Fig 1. Schematic diagram of the longitudinal study design.

Fig 1

Both plasma and saliva were collected for evaluation using liquid biopsy. For example, T2 samples were used to estimate the therapeutic effect of surgery based on T1 sampling data, and T3 samples were used to evaluate the efficiency of adjuvant therapies based on sampling T2 sampling data.