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. Author manuscript; available in PMC: 2021 Sep 3.
Published in final edited form as: Cell Rep Phys Sci. 2021 Jul 28;2(8):100515. doi: 10.1016/j.xcrp.2021.100515

Figure 3. The micromechanics of a collagen matrix is controlled by its microstructure.

Figure 3.

(A) The confocal reflection image showing the collagen fibers and the probe particle (arrow). Inset: a holographic image showing the same field of view.

(B) The particle displacements when an optical trap is projected at θ = 0° (red), 90° (green), 180° (blue), and 270° (magenta). The optical trap is projected at the same focal plane of the particle, and 0.7 μm from the unperturbed particle center. The power of the optical trap switches on and off at a frequency of 1 Hz.

(C) Confocal reflection images showing distinct collagen fiber networks self-assembled at 2 different temperatures, 37°C and 21°C.

(D) Spatial distributions of micromechanical compliance in 2 collagen matrices formed at 37°C and 21°C, respectively.

(E) Spatial distributions of micromechanical anisotropy in 2 collagen matrices formed at 37°C and 21°C, respectively.

Scale bars in (C)–(E): 50 μm. Adapted from Jones et al.36 Copyright (2016) National Academy of Sciences.