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. 2021 Jul 30;10(7):2450–2456. doi: 10.4103/jfmpc.jfmpc_2358_20

Table 1.

Inhibitory action of NSAIDs against COX-1 or COX2 enzymes

Drug IC50 for COX-1 IC50 for COX-2 Ratio [COX-2:COX-1] References
Celecoxib 30 µM 50 nM 600:1 [48,49]
300:1 [52]
[53]
Indomethacin 0.42 µM 2.75 µM 1:7 [48,49]
0.08 µM 1 µM 1:12 [53]
Diclofenac 0.06 µM 0.4 µM 7:1 [48,49]
0.01 µM 0.03 µM 3:1 [51,54]