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. 2021 Aug 16;15:638114. doi: 10.3389/fnint.2021.638114

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Copyright © 2021 Sun, Wang, Han, Meng, Han and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Constructed lncRNA-miRNA-mRNA network. Red circular nodes are upregulated mRNAs and blue circles are downregulated mRNAs. Dark-blue diamonds represent downregulated lncRNAs and purple diamonds represent upregulated lncRNAs. Orange triangles represent upregulated miRNAs and green triangles are downregulated miRNAs. Dotted lines demonstrate positively-correlated interactions of mRNAs and lncRNAs, straight lines with arrow represent interactions between miRNAs and mRNAs, and a straight line with T arrow means lncRNA-miRNA interaction. The size of node represents its degree.