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. 2021 Jun 6;4(3):646–664. doi: 10.20517/cdr.2021.34

Table 3.

Currently recruiting EBV CTL trials for PTLD

Study Intervention Disease status
NCT03131934
Phase I
Tacrolimus-resistant autologous EBV CTLs Newly diagnosed or rituximab refractory in SOT patients
NCT02779439
Phase I
HLA-matched third-party donor-derived specific CTLs Viral infection following allogeneic HCT or SOT
NCT02900976
Phase II
Rituximab + LMP-specific T cells Newly diagnosed, relapsed, or refractory in SOT patients
NCT03394365
Phase III
Tabelecleucel (1) SOT after failure of rituximab and rituximab plus chemotherapy; or (2) allogeneic HCT after failure of rituximab
NCT02822495
Expanded access
Tabelecleucel Relapsed/refractory in SOT and HCT patients

EBV CTLs: Epstein-Barr virus cytotoxic T cell lines; PTLD: post-transplant lymphoproliferative disorder; HCT: hematopoietic cell transplantation; LMP: latent membrane protein.