Table 3.
Currently recruiting EBV CTL trials for PTLD
| Study | Intervention | Disease status |
|
NCT03131934 Phase I |
Tacrolimus-resistant autologous EBV CTLs | Newly diagnosed or rituximab refractory in SOT patients |
|
NCT02779439 Phase I |
HLA-matched third-party donor-derived specific CTLs | Viral infection following allogeneic HCT or SOT |
|
NCT02900976 Phase II |
Rituximab + LMP-specific T cells | Newly diagnosed, relapsed, or refractory in SOT patients |
|
NCT03394365 Phase III |
Tabelecleucel | (1) SOT after failure of rituximab and rituximab plus chemotherapy; or (2) allogeneic HCT after failure of rituximab |
|
NCT02822495 Expanded access |
Tabelecleucel | Relapsed/refractory in SOT and HCT patients |
EBV CTLs: Epstein-Barr virus cytotoxic T cell lines; PTLD: post-transplant lymphoproliferative disorder; HCT: hematopoietic cell transplantation; LMP: latent membrane protein.