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. 2021 Aug 24;44(8):292–306. doi: 10.1097/CJI.0000000000000386

FIGURE 3.

FIGURE 3

Sensitive and selective HPV E711–19 primary binders (C1007 and C996; examples of the best binders in peptide-loading Jurkat:T2 assay). A, Comparison of the primary binders to the TCR (C882). B, Selectivity of the best primary binder compared with the TCR. Blue lines are the on-target dose-response curves. Other colors are near off-target curves. C, Near off-target peptide sequences for HPV E711–19 are listed in the inserted table. Primary binder: binders identified from primary HuTARG library. D, Examples of on-target and far off-target activity of primary binders against HPV E782–90. E, Examples of on-target activity of primary binders against HPV E77–15. CAR indicates chimeric antigen receptor; CMV, cytomegalovirus; HPV, human papillomavirus; TCR, T-cell receptor.