TABLE 4.
Significant between-group (NC-SCD, NC-aMCI, and NC-AD) differences in structural covariance networks seeding from the Ch4p and Ch1/2.
| Seed | Contrast | Peak region | MNI coordinates | Extent | Peak intensity | ||
|
|
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| X | Y | Z | |||||
| Ch4p | NC > SCD | Temporal_Mid_L | –52.5 | −51 | 1.5 | 133 | –3.5685 |
| NC > aMCI | Temporal_Sup_R | 55.5 | −30 | 16.5 | 5533 | –5.6571 | |
| NC > AD | Cingulum_Mid_R | 1.5 | 36 | 31.5 | 10790 | –5.0984 | |
| NC < SCD | Occipital_Mid_L | –40.5 | −72 | 3 | 126 | 3.5079 | |
| Ch1/2 | NC > SCD | ParaHippocampal_L | −30 | −18 | –22.5 | 1044 | –4.1796 |
| NC > aMCI | Temporal_Sup_R | 57 | −30 | 15 | 279 | –4.4193 | |
| NC > AD | Frontal_Sup_L | −24 | 6 | 64.5 | 1161 | –4.2794 | |
| NC < AD | Temporal_Pole_Sup_R | 55.5 | 16.5 | –13.5 | 287 | 3.8021 | |
Ch4p, cholinergic system of posterior nucleus basalis Meynert; Ch1/2, cholinergic system of combined clusters of the medial septum and the vertical limb of the diagonal band; AD, Alzheimer’s disease; NC, normal control; aMCI, amnestic mild cognitive impairment; SCD, subjective cognitive decline; MNI, Montreal Neurological Institute.