Table 2.
Incidence of Grade 1–4 Toxicities Throughout Afatinib Treatment
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | |||||
|---|---|---|---|---|---|---|---|---|
| Adverse event | N of pts | % pts | N of pts | % pts | N of pts | % pts | N of pts | % pts |
| Overall | 29 | 49.15 | 28 | 47.46 | 7 | 11.86 | 1 | 1.69 |
| Acne | 0 | 0.00 | 3 | 5.08 | 0 | 0.00 | 0 | 0.00 |
| Creatinine | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
| Cough | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
| Dermatitis | 1 | 1.69 | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 |
| Diarrhea | 6 | 10.17 | 21 | 35.59 | 2 | 3.39 | 0 | 0.00 |
| Dry skin | 0 | 0.00 | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 |
| Fatigue | 2 | 3.39 | 3 | 5.08 | 0 | 0.00 | 0 | 0.00 |
| Fever | 0 | 0.00 | 0 | 0.00 | 1 | 1.69 | 0 | 0.00 |
| Hemoglobin | 5 | 8.47 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
| Infection clinic | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 | 1 | 1.69 |
| Leucocytes | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
| Mucositis clinical | 4 | 6.78 | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 |
| Mucositis functional | 3 | 5.08 | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 |
| Nail changes | 1 | 1.69 | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 |
| Nausea | 2 | 3.39 | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 |
| Neuropathy sensory | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
| Neutrophils | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
| Nose bleeding | 2 | 3.39 | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 |
| Paronychia | 2 | 3.39 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
| Pain bone | 2 | 3.39 | 2 | 3.39 | 0 | 0.00 | 0 | 0.00 |
| Pain muscle | 2 | 3.39 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
| Pneumonitis | 2 | 3.39 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
| Pruritus | 3 | 5.08 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
| Pulmonary embolism | 0 | 0.00 | 0 | 0.00 | 1 | 1.69 | 0 | 0.00 |
| Rash | 16 | 27.12 | 4 | 6.78 | 3 | 5.08 | 1 | 1.69 |
| Stomatitis | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
| Vomiting | 0 | 0.00 | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 |
| Weakness | 1 | 1.69 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 |
Abbreviations: N, number; pts, patients.