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. 2021 Aug 16;12:678468. doi: 10.3389/fendo.2021.678468

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Copyright © 2021 Halabi, Richter, Mendez, Kähne, Spichiger, Salazar, Torres, Vergara, Seron-Ferre and Torres-Farfan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interactome depicting the pathways that were most significantly enriched by differentially expressed proteins identified by quantitative proteomics of white adipose tissue (WAT) from adult offspring. Comparison: adult offspring that had been gestated under control (LD) conditions and fed with high-fat diet (HFD) during 12 weeks from postnatal day 100 onwards (LD + HFD group) versus adult offspring that had been gestated under CPS conditions and fed with standard diet postnatally (CPS + SD). Red, upregulated protein; green, downregulated protein; white, protein related in the network without expression changes. Proteins connected with solid lines have direct links; those connected with dotted lines have indirect links. The set of proteins was grouped in the Ingenuity Top Network 1: Cellular Development, Cell Morphology, Cell-Mediated Immune Response, and Inflammatory Response pathways.