Figure 13.

This cartoon provides an overview of the processes reviewed here to be differentially affected by SP-A1 and SP-A2 gene products in the alveolus, the BAL/hypophase and the alveolar cells (macrophages and epithelial cells). These processes are detailed in Table 4. (A) shows a cartoon of such processes of the type II cell miRNome, inhibition of surfactant secretion and perhaps the size of lamellar bodies. No studies involving SP-A1 and SP-A2 have been carried out for the type I cells. This panel also depicts events occurring in the hypophase. These include surfactant reorganization, surfactant surface film, proteome, and protection of surfactant inhibition by serum proteins. Both SP-A1 and SP-A2 are needed for tubular myelin formation. (B) depicts a cartoon of SP-A1 and SP-A2-mediated processes that affect AM at baseline and/or in response to insults. These include differences in AM proteome, toponome, gene expression, miRNome, bacterial phagocytosis, pro-inflammatory cytokine production, expression of cell surface molecules, AM binding and actin cytoskeleton.