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. 2021 Aug 17;12:681639. doi: 10.3389/fimmu.2021.681639

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Copyright © 2021 Floros, Thorenoor, Tsotakos and Phelps

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sex differences of the AM proteome in response to in vivo rescue of SP-A KO mice with different human SP-A variants. (A, B) show differential effects of SP-A1 and SP-A2 in females (A) and males (B) in terms of various functional protein groups. Bubble size and number depict the number of proteins within each group (114). ARC, actin-related cytoskeletal; OX, oxidative stress; PBCF, protease balance/chaperone function; RDP, regulatory/developmental processes; ROI, regulation of inflammation.