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. 2021 Aug 17;12:681639. doi: 10.3389/fimmu.2021.681639

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Copyright © 2021 Floros, Thorenoor, Tsotakos and Phelps

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Actin-related differences between SP-A1 and SP-A2-exposed AM (110). The pattern of fluorescence (cells stained with AlexaFluor 488 phalloidin) of AM exposed chronically to SP-A2 or SP-A1 is shown and it is not identical. (A) depicts the mean intensity of fluorescence per pixel and shows significant differences between SP-A2 and SP-A1 AM. (B) shows the ratio (densitometric measurements) of F-actin to G-actin in different cell fractions from a Western blot stained with an anti-actin N-terminal antibody (Sigma #2103). This ratio is lower in SP-A2 AM. (C) depicts significant differences between SP-A1 and SP-A2 in the levels of ARP3 obtained from proteomics data. Arp3 regulates actin polymerization and is part of the Arp2/3 complex, where several signaling pathways leading to actin polymerization converge.