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. 2021 Aug 17;8:657614. doi: 10.3389/fmed.2021.657614

Figure 3.

Figure 3

Intraglomerular crosstalk based on ligand-receptor pair analysis of scRNA-seq. Pairs in orange frames come from the analysis of kidney of human with early diabetic nephropathy. Pairs in purple frames come from the analysis of kidney of diabetic mice. SLIT3, slit guidance ligand 3; ROBO2, roundabout guidance receptor 2; NAMPT, Nicotinamide phosphoribosyltransferase; INSR, insulin receptors; CCN1, cellular communication network factor1; ITGB3/5, integrin beta3/5; ITGAV, integrin subunit alpha-V; Tgfb3, Transforming growth factor 3; Sdc4, syndecan 4; Notch3, notch reporter 3; Tmem108, transmembrane protein 108; NRG3, neuregulin-3; ERBB4, Erb-B2 receptor tyrosine kinase 4; Bmp2, bone morphogenetic protein 2; Bmp7, bone morphogenetic protein 7; Bmpr2, bone morphogenetic protein receptor 2; Epha3, erythropoietin-producing hepatocellular carcinoma A3; VEGFA, vascular endothelial growth factor A; Flt1(VEGFR1, vascular endothelial growth factor receptor 1; Kdr (VEGFR2), vascular endothelial growth factor receptor 2; Angpt, angiopoietin; Tie (Tek): angiopoietin 1 receptor; Efnb2, ephrin B2; Efna1, ephrin A1; LTBP1, latent transforming growth factor (TGF)-beta binding protein-1; Cdh5, cadherin 5; Dag1, dystroglycan 1; Sema6a, semaphorin 6a; Itm2b, Integral membrane protein 2B; Cdf5, cycling dof factors 5; EFEMP1, Epidermal Growth Factor-containing Fibulin-like Extracellular Matrix Protein 1; EGFR, Epidermal Growth Factor Receptor. [Pairs in orange are summarized from Mitu et al. (93) and pairs in purple are summarized from Fu et al. (35)].