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. 2021 Aug 17;12:730931. doi: 10.3389/fpsyt.2021.730931

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Copyright © 2021 Germann, Mameli, Elias, Loh, Taha, Gouveia, Boutet and Lozano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Habenula anatomy and connections. (A) The human habenula illustrated in orthogonal slices using the MNI template brain (MNI152b) (16). (B) Highlighting regions connected with the habenula (17–20) illustrated using a medial view of a high-resolution, high contrast template (21). The habenula is highlighted in purple. Areas with direct connections to the habenula are highlighted in blue; areas that are functionally associated with the habenula are highlighted in green. a, areas; Amy, amygdala; BFB, basal forebrain; BG, basal ganglia; Hc, hippocampus; Hypo, hypothalamus; IPN, interpeduncular nucleus; mPFC, medial prefrontal cortex; NBM, nucleus basalis of Meynert; PAG, periaqueductal gray; PFC, prefrontal cortex; RMT, rostromedial tegmental nucleus; RN, raphe nuclei; SN, substantia nigra; Th, thalamus; VTA, ventral tegmental area; *approximate/example position of the region.