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. 2021 Aug 17;15:655695. doi: 10.3389/fnsys.2021.655695

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Copyright © 2021 Lian, Zhu, Sun and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anesthesia/surgery influences neurobehaviors in aged mice. (A) Experimental timeline of the Morris water maze test. (B) Escape latency to reach the hidden platform during the 5 days of training (two-way ANOVA, p < 0.05). (C) Swimming speed during hidden platform training (two-way ANOVA, p > 0.05). (D) Difference in swimming speed between the two groups during the probe test (unpaired t-test, p > 0.05). (E,F) Time spent in the target quadrant during the probe test (unpaired t-test, *p < 0.05). A + S: anesthesia/surgery. *p < 0.05 (n = 10 for both sham and A + S groups).