TABLE 2.
α-Glucosidase inhibitory activity of aspulvinones 1–6.
| Compounds | IC50 (µM)a | Ki (µM)b | KI (µM) | KIS (µM) | Inhibition mode |
|---|---|---|---|---|---|
| 1 | 2.2 ± 0.4 | 6.60 | 3.15 | 8.23 | mixed-type |
| 2 | 32.0 ± 5.8 | NTc | NT | NT | NT |
| 3 | 38.6 ± 5.2 | NT | NT | NT | NT |
| 4 | 4.6 ± 1.3 | 6.58 | 4.70 | 6.62 | mixed-type |
| 5 | 44.3 ± 8.9 | NT | NT | NT | NT |
| 6 | 10.8 ± 2.3 | NT | NT | NT | NT |
| Acarbosed | 17.2 ± 1.8 | NT | NT | NT | NT |
a
Sample concentration which led to 50% enzyme activity loss.
b
Ki is the inhibition constant.
c
NT is not tested.
d
Acarbose is used as a positive control.