Table 3.

Mendelian randomization estimates of Graves’ disease on rheumatoid arthritis.

Outcome	Method	OR	95% CI	P-value	MR-Egger intercept (P-value)	Statistical power
Rheumatoid arthritis	Inverse variance weighted	1.30	0.94–1.80	0.112		1
	MR-Egger	1.01	0.32–3.19	0.984	0.07 (0.663)
	Weighted median	1.07	0.97–1.18	0.067
Rheumatoid arthritis*	Inverse variance weighted	1.35	0.95–1.94	0.097		1
	MR-Egger	1.06	0.30–3.76	0.927	0.07 (0.702)
	Weighted median	1.14	1.03–1.26	0.015

The two sets of SNPs associated with RA are independent.

*Previous summary data of rheumatoid arthritis from GWAS conveyed by Okada et al.