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. 2021 Aug 17;12:702472. doi: 10.3389/fphar.2021.702472

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Copyright © 2021 Chen, Wang, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemical structure of different natural compounds targeting (A) 3CL^pro (I), (B) both 3CL^pro and PL^pro, and (C) PL^pro (II). Quercetin-3-β-galactoside (6), quercetin (22), curcumin (31), and kaempferol (57) inhibit both 3CL^pro and PL^pro but are not repeatedly displayed in (B).