FIGURE 5.

Multitarget based screening of anticancer natural compounds. Pro-inflammatory mediators like TNFα, JL2, JL12, etc. binds to the receptor on the cell surface which undergoes a conformational change and activates JNK 1/2. JNK1/2 phosphorylation leads to apoptosis that releases inflammatory factors like NFKβ that also releases inflammatory factors like TNF-α which plays role in cell death amplification. IL6 activates JAK/STAT pathway that results in cancer cell proliferation. TGFFβ also activates various pathways leading to liver fibrosis. EGFR binds to the cell surface receptor that activates GRB2. Phosphorylation of GRB2 activates the downstream pathway as GABI further activates P13K that activates AKT leading to cell survival. Natural fragments like indole, quinoline, isoquinoline, and piperidine inhibit both the inflammation pathway and EGFR in cancer cell growth.