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. 2021 Aug 17;11:684984. doi: 10.3389/fonc.2021.684984

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Copyright © 2021 Guo, Liu, Peng, Wang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of MIR31HG in controlling CRC growth and metastasis in vivo. The suspension of SW480 and HCT116 cells overexpressing MIR31HG was used to construct the xenograft model in vivo. (A) The nude mice were sacrificed at the 4^th week after tumor cell injection, and the tumor images were shown. (B, C) Tumor volume and weight was counted. (D) IHC was used for detecting KI67 in the tumor tissues. The rate of KI67-positive cell was counted. (E, F) Lung metastasis assay was used for evaluating the metastasis of CRC cells with forced MIR31HG upregulation. The number lung metastase was counted. (G) IHC was used for detecting VEGFA in the tumor tissues. (H, I) WB was used to detect the expression of PKM2, GLUT1 and HK2 as well as CD31 and VEGFA in the tumor tissues. ns P > 0.05 (vs Blank group). *P < 0.05, **P < 0.01, ***P < 0.001 (vs.vector group). (n=5).