Figure 5.

si-ADAM17 inhibits the effects of miR-28-3p inhibitor on cell proliferation and apoptosis in S-protein-treated 293T cells. (A) ADAM17 levels were analyzed after transfection of miR-28-3p inhibitor or co-transfection of miR-28-3p inhibitor and si-ADAM17 by WB. (B) S-protein-treated 293T cell proliferation was measured using the MTT assay. (C) S-protein-treated 293T cell apoptosis was measured using the TUNEL assay. ^*P<0.05 vs. inhibitor-NC; ^#P<0.05 vs. inhibitor + si-ADAM17. WB, western blotting; S-protein, spike protein; ADAM17, A disintegrin and metalloproteinase 17; RT-qPCR, reverse-transcription quantitative polymerase chain reaction; NC, negative control; si, small interfering.