Table 2.
P16 methylation in GSM samples.
| Tumor [N, (%)] | p | Normal [N, (%)] | p | |
|---|---|---|---|---|
| Overall (n=81) | 51 (63.0) | 26 (32.1) | 0.001 | |
| Gender | ||||
| Male (n=63) | 39 (61.9) | 0.71 | 24 (38.1) | 0.03* |
| Female (n=18) | 12 (66.7) | 2 (11.1) | ||
| Age | ||||
| ≤59 (n=16) | 8 (50.0) | 0.25 | 3 (18.8) | 0.43 |
| 60-69 (n=44) | 27 (61.4) | 16 (36.4) | ||
| ≥70 (n=21) | 16 (76.2) | 7 (33.3) | ||
| Smoke | ||||
| Yes (n=51) | 35 (68.6) | 0.17 | 19 (37.3) | 0.20 |
| No (n=30) | 16 (53.3) | 7 (23.3) | ||
| Alcohol | ||||
| Yes (n=41) | 31 (75.6) | 0.02* | 16 (39.0) | 0.18 |
| No (n=40) | 20 (50.0) | 10 (25.0) | ||
| Family history | ||||
| Yes (n=57) | 39 (68.4) | 0.12 | 42 (33.3) | 0.71 |
| No (n=24) | 12 (50.0) | 12 (29.2) | ||
| Pathological subtype | ||||
| ESCC | 46 (62.3) | 0.94 | 23 (31.8) | 0.83 |
| EAC | 5 (71.4) | 3 (42.9) | ||
| Tumor stage | ||||
| T1-2 (n=23) | 13 (56.5) | 0.45 | 7 (30.4) | 0.84 |
| T3-4 (n=58) | 38 (65.5) | 19 (32.8) | ||
| N0 (n=36) | 21 (58.3) | 0.44 | 10 (27.8) | 0.46 |
| N1-3 (n=45) | 30 (66.7) | 16 (35.6) |
*the difference is significant.