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. 2021 Aug 12;11:581671. doi: 10.3389/fonc.2021.581671

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Copyright © 2021 Pradhan, Kumar, Surya H, Krishna, John, Jissa, Anjana, Chandramohan and Nair

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of SANT1 treatment and STIL inhibition on Shh and Wnt signaling. (A, B) Bar graph showing expression of Shh signaling components upon SANT1 treatment and STIL silencing. (C, D) Western blot showing effect of SANT1 treatment and STIL silencing on GLI2, β-catenin, AKT, and p-AKT protein expression. (E) Schematic representation showing possible mechanistic regulation of multifaceted role by STIL in CRC. Unpaired t-test results showing p value ≤ 0.05, ≤ 0.01 are represented by *, **, respectively; ns, not significant.