Table 3.

Outside the Bone Marrow: IgM Related Symptoms

Clinical Features	IgM Related Disease
New onset headaches, blurred vision, mucosal bleeding, hearing loss, tinnitus, neurologic disorders, retinopathy and retinal hemorrhage	Hyperviscosity
Distal, symmetric, progressive, sensorio-motor peripheral neuropathies with predominantly demyelinating features in the nerve conduction studies. (50% of cases anti-MAG +) IgM antibodies against other neural targets: gangliosides GM1, GD1a, GD1b, GT1b, GM2 and GM3 and the paragloboside, sulphate-3-glucuronyl para-globoside (SGPG).	Peripheral neuropathies related to IgM
Raynaud like symptoms, acrocyanosis, ulcerations on extremities, purpura, cold urticaria	Cryoglobulinemia I
Arthralgias, sensorimotor neuropathies, purpura, renal failure.	Cryoglobulinemia II
Extra vascular Hemolytic anemia (cold exposure), Raynaud phenomenon, acrocyanosis.	Cold agglutinins
Recurrent thrombotic events	Antiphospholipid syndrome
Peripheral sensory neuropathies with axonal pattern associated with autonomic nerve dysfunction. Other organ involvements: kidneys, heart, lung, liver and Gastointestinal tracts.	Amyloidosis AL
Chronic urticarial eruptions, recurrent fever, arthralgia ± lymphadenopathy	Schnitzler’s Syndrome, (Auto-inflammatory disease)
Renal Failure ± Proteinuria (Moncolnal- IgM +/_ Light chain deposition)	Proliferative glomerulonephritis, Amyloidosis AL Cryoglobulinaemia II