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Selection for bacteria with increased vancomycin resistance during the bactericidal action of vancomycin. (Top panel) Effect of vancomycin (30 μg/ml added at the time indicated by arrow) on the viable titers of strains RR4 (○) and RR8 (■). (Bottom panels) Population analysis of the two strains before (○) and after (■) the massive population shift caused by vancomycin treatment.
