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. 2021 Aug 12;15:718720. doi: 10.3389/fncel.2021.718720

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Copyright © 2021 Ju, Yang, Jiang, Wang, Zhang, Zhao, Fang, Liao, Zheng, Li, Hou, Liang, Pan, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered lipidomic profile in 16p11.2^± striatum. Lipidomics analysis was performed with striatum tissues from P60 16p11.2^± mice (n = 5) and WT controls (n = 6). A total of 32 lipid classes and 1218 lipid species were detected. (A) Charts illustrating all detected lipid classes. Each tail number indicates the number of lipid species detected. (B–D) Comparison of lipid classes of glycerolipids (B), saccharolipids (C), and sphingolipids (D) in 16p11.2^± mice versus WT controls. Data were analyzed with unpaired t tests (mean ± SEM, *p < 0.05). Cer, ceramide; CerG1, hexosyl ceramide; CerG2, dihexosyl ceramide; DG, diglyceride; GM1, gangliosides 1; GM2, gangliosides 2; GM3, gangliosides 3; MG, monoglyceride; MGDG, monogalactosyldiacylglycerol; SM, sphingomyelin; So, sphingosine; SQDG, sulfoquinovosyldiacylglycerol; ST, sulfatide; TG, triglyceride.