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. 2021 Aug 18;9:705263. doi: 10.3389/fcell.2021.705263

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Copyright © 2021 Larkin, Nguyen, Hou, Glastras, Chen, Wang, Pollock and Saad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Renal fibrotic changes as measured by collagen IV. (A) mRNA expression of collagen IV, (B) representative images of collagen IV staining at 200× magnification, and quantitation. Results expressed as mean ± SEM, n = 6. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. CC, control offspring; HC, lean offspring of obese mothers; CH, obese offspring of lean mothers; HH, obese offspring of obese mothers; CC + GH, control offspring exposed to gestational hydralazine; HC + GH, lean offspring of obese mothers with gestational hydralazine; CH + GH, obese offspring of lean mothers with gestational hydralazine; HH + GH, obese offspring of obese mothers with gestational hydralazine.