Table 1.

Parameter and reference values of the model as depicted in Figure 2.

Parameter	Description	Value	References
nWnt	total Wnt	1
nLRP6	total LRP6	4,000	Bafico et al., 2001
CK1γ	total CK1γ	5,000	Haack et al., 2015
nbetacyt	β-catenin in cytosol	12,992	Lee et al., 2003; Mazemondet et al., 2012
nbetanuc	β-catenin in nucleus	5,283	Lee et al., 2003; Mazemondet et al., 2012
nAxin	unphosphorylated Axin	220	Lee et al., 2003; Mazemondet et al., 2012
nAxinP	phosphorylated Axin	253	Lee et al., 2003; Mazemondet et al., 2012
nLR	total number of Lipid rafts	1–30,000	Pralle et al., 2000; Prior et al., 2003
k1	Raft Shuttling	$3.61·10^5\frac{1}{\text{Ms}}$	Lauffenburger and Linderman, 1996
k2	Wnt synthesis	4.5·10−09 to $4.5·10^{-10}\frac{\text{M}}{\text{min}}$
k3	Wnt degradation	0.27 $\frac{\text{1}}{\text{min}}$	Lee et al., 2003; Haack et al., 2015
k4	Wnt LRP6 association	$2.16·10^6\frac{1}{\text{Mmin}}$	Bourhis et al., 2010
k5	Wnt LRP6 dissociation	0.02 $\frac{\text{1}}{\text{min}}$	Bourhis et al., 2010
k6	LRP6 phosphorylation	$2.412·10^9\frac{1}{\text{Mmin}}$	Haack et al., 2015
k7	LRP6 dephosphorylation	$4.7·10^{-2}\frac{1}{\text{min}}$	Haack et al., 2015
k8	Axin/LRP6 binding	$2.629·10^{12}\frac{1}{\text{Mmin}}$	Haack et al., 2015
k9	Axin/LRP6 dissociation	$3·10^{-4}\frac{1}{\text{min}}$	Haack et al., 2015
k10	Axin phosphorylation	$0.03\frac{1}{\text{min}}$	Lee et al., 2003; Mazemondet et al., 2012
k11	Axin dephosphorylation	$0.03\frac{1}{\text{min}}$	Lee et al., 2003; Mazemondet et al., 2012
k12	Axin degradation	$4.48·10^{-3}\frac{1}{\text{min}}$	Lee et al., 2003; Mazemondet et al., 2012
k13	β-catenin induced Axin synthesis	$7.6086·10^{-10}\frac{1}{\text{Mmin}}$	Lee et al., 2003; Mazemondet et al., 2012
k14	β-catenin synthesis	$1.14·10^{-09}\frac{\text{M}}{\text{min}}$	Lee et al., 2003; Mazemondet et al., 2012
k15	β-catenin basal degradation	$1.13·10^{-4}\frac{1}{\text{min}}$	Lee et al., 2003; Mazemondet et al., 2012
k16	Axin induced β-catenin degradation	$1.104·10^8\frac{1}{\text{Mmin}}$	Lee et al., 2003; Mazemondet et al., 2012
k17/18	β-catenin nucleus shuttling	$2.886·10^{11}\frac{1}{\text{Mmin}}$	Lee et al., 2003; Mazemondet et al., 2012

M corresponds to mol/l.