TABLE 3.

Metabolite pathway changes in hippocampus.

No.	Pathway	Total	Hits	Raw p	Log(p)	Holm adjust	FDR	Impact
1	Aminoacyl-tRNA biosynthesis	48	2	0.01	1.86	1.00	0.33	0.00
2	Alanine, aspartate, and glutamate metabolism	28	2	0.00	2.32	0.40	0.33	0.20
3	Histidine metabolism	16	1	0.06	1.21	1.00	0.52	0.00
4	Valine, leucine, and isoleucine biosynthesis	8	1	0.03	1.50	1.00	0.38	0.00
5	Butanoate metabolism	15	1	0.06	1.23	1.00	0.52	0.00
6	Propanoate metabolism	23	1	0.09	1.05	1.00	0.57	0.00
7	Nitrogen metabolism	6	1	0.02	1.63	1.00	0.33	0.00
8	Biosynthesis of unsaturated fatty acids	36	2	0.01	2.11	0.65	0.33	0.00
9	Linoleic acid metabolism	5	1	0.02	1.70	1.00	0.33	1.00
10	Pantothenate and CoA biosynthesis	19	1	0.07	1.13	1.00	0.54	0.00
11	D-Glutamine and D-glutamate metabolism	6	1	0.02	1.63	1.00	0.33	0.50
12	Selenocompound metabolism	20	1	0.08	1.11	1.00	0.54	0.00
13	Arginine biosynthesis	14	1	0.05	1.26	1.00	0.52	0.12

Hits represent the matched number of metabolites in the pathway. Raw p represents the original p-value calculated from the enrichment analysis. Holm p represents the p-value further adjusted using the Holm–Bonferroni method. FDR (false discovery rate) represents the p-value adjusted using false discovery rate.