Table 1.
Major “CD8+ Treg” subsets.
| Subset | Precursor | Differentiation condition | Present in young naïve mice | Function | Ref |
|---|---|---|---|---|---|
| CD8+Foxp3+ | Mature naïve CD8+ T cells (?) | Alloantigen transplantation | None to low | Suppress effector T cell responses and immune rejection | (2–7) |
| CD8+CD103+ (vitro) | Mature naïve CD8+ T cells | In vitro TCR stimulation with TGF-β | None | Suppress immune rejection | (8, 9) |
| CD8+CD103+ (tumor) | Mature naïve CD8+ T cells | In vivo tumor growth | None | Negatively correlated with tumor control | (10) |
| CD8+CD28- | Mature naïve CD8+ T cells (?) | Age-dependent accumulation | None | Suppress effector T cell responses | (11–14) |
| CD8+CD122+ CD49d+ | Mature naïve CD8+ T cells (?) | In vivo TCR stimulation | Low | Suppress immune rejection | (15–18) |
| CD8+CD122+ Ly49+ | unknown | Unknown in vivo differentiation process | Present | Suppress GC reaction | (19, 20) |