Table 2.

T_FR and CD8⁺CD122⁺Ly49⁺ comparison.

	TFR	CD8+CD122+Ly49+
T cell subset	CD4+	CD8+
Regulatory identity-TF	Foxp3+ (Helios+/-?)	Foxp3-Helios+
Other TF	Bcl6+	Eomes+
Common surface marker	CXCR5+	CXCR5+
Mitigate spontaneous GC/autoimmunity	Mostly no	Yes
Effector molecules	IL-10, neuritin	Perforin, FasL
Function in GC	Promote GC during viral infection and peanut allergic responses; Suppress early GC following protein immunization and HDM allergic responses.	Suppress GC
Targeting cells	CD4+ and B	CD4+