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In a pathway independent of transcription, the mitochondrial p53 is bonded to Bcl-2 oncoprotein and Bcl-x proteins which reduce their inhibitory effect on the Bak and Bax apoptotic proteins. Bcl-2 promoted cell survival by blocking chemotherapy-induced apoptosis. Therefore, p53 leads to mitochondrial permeability and cytochrome C release consequently and activation apoptosis (21).
