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. 2021 Aug 18;12:697162. doi: 10.3389/fimmu.2021.697162

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Copyright © 2021 Seo, Jeong, Baek, Choi, Choi, Ko and Kweon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bleomycin-induced lung injury releases self-DNA that activates cGAS-STING pathway. Activated cGAS-STING pathway affects to enhanced IFN-I transcription, and pDCs are responsible for increased antiviral effects.