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. 2021 Aug 18;12:703986. doi: 10.3389/fimmu.2021.703986

Figure 1.

Figure 1

Standard study schedule, immune response to EBOV GP, and survival after EBOV challenge. (A) Each study described followed a standard schedule in which cynomolgus macaques were vaccinated at three-week intervals with either two or three doses of vaccine. Controls received adjuvant only. Serum or plasma samples were collected periodically. Animals were challenged with 1,000 PFU of virus at week 10 after initial vaccination. (B) Anti-EBOV GP IgG antibodies were measured by MIA at time points relative to first vaccination with EBOV GP. Samples were assayed in triplicate. Each data point for vaccinated groups represents geometric mean ± 95% confidence interval whereas data points for controls were plotted per individual animal. The dashed grey line marks the threshold for positive detection of anti-EBOV GP IgG at 3 standard deviations (SD) above mean MFI of negative control samples. (C) Kaplan-Meier survival curves after challenge with EBOV. *p < 0.05, **p < 0.01, ***p < 0.001.