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. 2021 Aug 18;9:694834. doi: 10.3389/fpubh.2021.694834

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Copyright © 2021 Her Majesty the Queen in Right of Canada.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HepaRG™ cell viability measured using the CellTiter-Glo^® Luminescent Cell Viability Assay for (A) DDI (Group 1) chemicals and (B) non-DDI (Group 2 and 3) chemicals. DDI chemical abbreviations: aflatoxin B1 (AFB1), benzo[a]pyrene (BaP), cisplatin (CISP), cyclophosphamide (CP), cytosine arabinoside (AraC), methyl methanesulfonate (MMS), N-ethyl-N-nitrosourea (ENU), zidovudine (ZVD), and propyl gallate (PG; included with Group 1 chemicals). Non-DDI chemical abbreviations: 2-deoxy-D-glucose (2DG), eugenol (EUG), and Urea. The test concentrations for each chemical are shown in Table 2 (C1 is the lowest concentration and C5 is the highest concentration). The red line represents the cytotoxicity threshold of <40% cell viability.