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. 2021 Aug 18;8:710676. doi: 10.3389/fmolb.2021.710676

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Copyright © 2021 Zhang, Xu, Yang, Yang, Fang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Santamarine harbors cancer-selective antiproliferative activity. (A) Cell viability of cancer cell lines (HeLa, HepG2, HL-60, and MDA-MB-231) and noncancerous cell lines (BEAS-2B and L02) after treatment with santamarine. The viability was detected by the MTT assay after cells were incubated with increasing concentrations of santamarine for 48 h (B) HeLa cell viability assays in 24, 48, and 72 h were carried out as in (A), with a range of concentrations of santamarine. The results of each cell line were normalized to untreated controls. (n = 3 biological replicates, data are mean ± s. d. **p < 0.01 vs. the BEAS-2B group in (A), and the control group in (B).