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. 2021 Aug 18;12:727681. doi: 10.3389/fmicb.2021.727681

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Copyright © 2021 Zhai, Niu, Liu, Lin and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oral administration of ELE improved DSS induced colon length shortening and epithelial destruction. (A) Representative picture of colon length. (B) Colon length of mice in each group, n = 10–12 mice/per group. (C) The crypt depth of mice in colon, n = 6 mice/group. (D) Representative picture of colon epithelium, objective × 20, the scale indicates 100 μm. (E) The relative mRNA expression level of Toll-like receptor 4 (TLR4), IL-6, and IL-10 in colon, n = 9–12 mice/group. Differences in data in mouse subjects were assessed by one-way ANOVA. *p < 0.05; ***p < 0.001.