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. 2021 Aug 18;12:727681. doi: 10.3389/fmicb.2021.727681

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Copyright © 2021 Zhai, Niu, Liu, Lin and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ELE on the gut microbiota in mice. (A) The NMDS plot of gut microbiota. (B) The Venn plot based on OTUs of gut microbiota. (C) The OS, diversity, and abundance index of gut microbiota. (D) Oral administration of ELE regulates the microbiota of IBD mice in phylum level. (E) Oral administration of ELE regulates the microbiota of IBD mice in family level. (F) Identification of characteristic microbiota in cecal contents of mice with different treatments by LEfSe analysis, (a) LefSe taxonomic cladogram and (b) LDA score. n = 7–8 mice/group. Differences in data in mouse subjects were assessed by one-way ANOVA. *p < 0.05; **p < 0.01; ***p < 0.001. NMDS, non-metric multidimensional scaling. OTU, operational taxonomic unit; LEfse, LDA effect size; LDA, linear discriminant analysis.