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. 2021 Aug 18;12:676662. doi: 10.3389/fimmu.2021.676662

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Copyright © 2021 Loeven, Maciej-Hulme, Yanginlar, Hubers, Kellenbach, de Graaf, van Kuppevelt, Wetzels, Rabelink, Smith and van der Vlag

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Factor H and recombinant FHR1 and FHR5 bind to glomerular endothelial cells in vitro. Factor H-related proteins (FHRs) 1 (A), 2 (B) and 5 (C) and factor H (D) were titrated on conditionally immortalized glomerular endothelial cells (ciGEnCs) and binding was determined using ELISA. Labeling antibody-sensitized ciGEnCs with C3b using classical pathway proteins (n=7) (E) significantly increased binding of factor H and FHR1 and FHR5 (n=3) (F). (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs Unlabeled).