Figure 3.

Aged neutrophils have high PD-L1 and arginase-1 expression in TN patients. (A) The Spearman’s correlation of neutrophil characters presented in a heatmap. The colored scale bar ranging from blue to red (−1 to 1) corresponds to negative and positive correlations, respectively. The size of the circle represents the p-value. (B) Correlation between CD62L^loCXCR4⁺ and PD-L1 expression on neutrophils in HIV-1-infected patients. (C) Comparison of PD-L1 expression on neutrophils in HIV-1 patients. (D) Comparison of the plasma-derived arginase-1 in HIV-1-infected patients. (E) Correlation between CD62L^loCXCR4⁺ and plasma arginase-1 levels in TN patients. (F) Correlation between PD-L1 expression on neutrophils with arginase-1 in HIV-1 TN patients. For statistical analyses, Mann–Whitney U-test was performed. Correlations were calculated using Pearson’s correlations. **p < 0.01, ***p < 0.001, ns, not significant.