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. 2021 Aug 18;12:670616. doi: 10.3389/fimmu.2021.670616

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Copyright © 2021 Liu, Huang, Yang, Jiao, Zhang, Song, Zhang, Zhou, Yuan, Cao, Mu, Zhou, Li, Shi, Xu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PD-L1 and arginase-1 expression is accompanied by neutrophil aging in vitro. (A) Percentage of CD62L^loCXCR4⁺ neutrophils increased after in vitro culturing. Neutrophils were cultured in vitro for 48 h, and the expression of CD62L and CXCR4 was detected using FACS. (B) Dynamics of CD62L^loCXCR4⁺ neutrophils and PD-L1 expression after in vitro culturing. (C) Relationship between the percentage of CD62L^loCXCR4⁺ neutrophils and PD-L1 MFI expression. (D) Dynamic change of arginase-1 secretion after neutrophils was cultured in vitro. (E) Correlation between the proportion of CD62L^loCXCR4⁺ neutrophils and arginase-1 production. For statistical analyses, Mann–Whitney U-test was performed. Correlations were calculated using Pearson’s correlations.