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. 2021 Aug 16;12:722027. doi: 10.3389/fimmu.2021.722027

Figure 2.

Figure 2

In absence of antigen re-exposure, asymptomatic individuals lose SARS-CoV-2-specific IgG-S responses more rapidly than symptomatic patients do. IgM and IgG recognizing the RBD of the spike protein (‘S’) and the nucleoprotein (‘N’) of SARS-CoV-2 were quantified by capture chemi-luminescence immunoassays (CLIA) for 29,177 samples obtained from 25,091 patients. (A, B) Plasma antibody levels of IgM-S, IgM-N, IgG-S, and IgG-N in samples obtained from asymptomatic (red) and symptomatic (blue) patients obtained during April 2020 and October 2020 are presented. The line shows the mean value calculated using a Lowess regression model and the shaded area represents the 95% confidence interval. The boxes in (B) show medians (middle line), 75% quartiles (upper bound) and 25% quartiles (lower bound), and the whiskers show 1.5-fold the IQR above and below the box. Repeated measures (mixed model) ANOVA was used for statistical analysis. ns, no significance, *p < 0.05; **p < 0.01; ***p < 0.001, ****p < 0.0001, two-sided. (C) Antibody positivity rates of asymptomatic (red) and symptomatic (blue) groups tested at indicated months after the epidemic ended are shown. The table below the figure depicts the numbers of assessed patients at indicated time points. Chi-square test was used for statistical analysis. ns, no significance, *p < 0.05; **p < 0.01; ***p < 0.001, ****p < 0.0001, two-sided.