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. 2021 Aug 18;11:643039. doi: 10.3389/fonc.2021.643039

Figure 6.

Figure 6

The effect of LINC00284-mediated miR-30d-5p silencing on the tumorigenic ability of thyroid cancer cells. (A) Representative pictures of xenograft tumors in nude mice. (B) Statistical analysis of the tumor volume in nude mice. (C) Statistical analysis of the tumor weight in nude mice. (D) The expression of LINC00284, miR-30d-5p, and ADAM12 mRNA in tumor tissues was determined using RT-qPCR. (E) The expression of ADAM12 in tumor tissues measured using Western blot analysis. *p < 0.05 compared with mice injected with oe-NC-infected cancer cells, # p < 0.05 compared with mice injected with LV-NC-infected cancer cells, and & p < 0.05 compared with mice injected with oe-LINC00284+ LV-NC-infected cancer cells. Data are presented as the means ± standard deviations. Comparisons between two groups were analyzed using the unpaired t-test, comparisons among multiple groups were analyzed using one-way ANOVA followed by Tukey’s post hoc test, and comparisons among groups at different time points were analyzed using repeated measures ANOVA with Tukey’s post hoc test. The experiments were repeated three times.