Figure 1. Flowchart of trial screening and inclusion.

Of 1877 trials identified on https://clinicaltrials.gov/ (February 20, 2020), 841 were excluded, for a final total of 1036 phase III randomized clinical trials assessing therapeutic interventions in patients with cancer. Of those, 790 trials had peer-reviewed manuscripts of primary study endpoint, and were included in primary analysis for this manuscript.