Table 4.
Allele and genotype frequencies of CPFE vs. PAC comparison.
| SNP/gene | CPFE | PAC | p | p * | OR | CI 95% | ||
|---|---|---|---|---|---|---|---|---|
| n = 16 (%) | n = 174 (%) | |||||||
| rs2609255/FAM13A | ||||||||
| TT | 6 | (37.5) | 80 | (51.4) | 0.43 | 0.99 | 0.57 | 0.20–1.66 |
| TG | 8 | (50) | 67 | (41.3) | 0.6 | 0.99 | 1.34 | 0.47–3.76 |
| GG | 2 | (12.5) | 10 | (7.3) | 0.3 | 0.99 | 2.1 | 0.41–10.54 |
| T | 20 | (64) | 227 | (72.3) | 0.3 | 0.3 | 0.64 | 0.30–1.38 |
| G | 12 | (36) | 87 | (27.7) | 1.55 | 0.72–3.32 | ||
| rs2736100/TERT | ||||||||
| AA | 1 | (6.3) | 63 | (42.5) | 0.04 | 0.99 | 0.08 | 0.01–0.69 |
| AC | 7 | (43.7) | 55 | (37.1) | 0.59 | 0.99 | 1.31 | 0.46–3.72 |
| CC | 8 | (50) | 30 | (20.4) | 0.01 | 0.99 | 3.93 | 1.36–11.33 |
| A | 9 | (28.1) | 181 | (61.1) | <0.01 | <0.01 | 0.24 | 0.11–0.55 |
| C | 23 | (71.9) | 115 | (38.9) | 4.02 | 1.79–8.99 | ||
| rs2076295/DSP | ||||||||
| TT | 7 | (43.75) | 63 | (37.7) | 0.78 | 0.99 | 1.28 | 0.45–3.61 |
| TG | 2 | (12.5) | 82 | (49.1) | <0.01 | 0.99 | 0.14 | 0.03–0.67 |
| GG | 7 | (43.75) | 22 | (13.2) | <0.01 | 0.99 | 5.12 | 1.73–15.16 |
| T | 16 | (50) | 208 | (62.2) | 0.18 | 0.91 | 0.6 | 0.29–1.25 |
| G | 16 | (50) | 126 | (37.8) | 1.65 | 0.79–3.14 | ||
| rs111521887/TOLLIP | ||||||||
| CC | 2 | (12.5) | 18 | (11.5) | 1 | 0.99 | 1.09 | 0.22–5.21 |
| CG | 14 | (87.5) | 138 | (88.5) | 1 | 0.99 | 0.91 | 0.19–4.34 |
| GG | 0 | (0) | 0 | (0) | NA | NA | NA | NA |
| C | 18 | (56.2) | 174 | (55.7) | 1 | 0.26 | 1.01 | 0.48–2.12 |
| G | 14 | (43.7) | 138 | (44.3) | 0.98 | 0.47–2.04 | ||
Genotypes and alleles frequencies were compared by Fisher exact test (p). Significant differences were demonstrated when p < 0.05.
*
p: value adjusted by age, sex, and tobacco index, by a binary logistic regression model. SNP, Single Nucleotide Polymorphism; CPFE, Patients with Combined Pulmonary Fibrosis and Emphysema Syndrome; PAC, Pulmonary Aging Cohort subjects; OR, Odds ratio; CI, 95%, Confidence interval 95%; NA, Not apply.