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. 2021 Aug 16;11:698835. doi: 10.3389/fonc.2021.698835

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Copyright © 2021 Huang, Lian, Dong, Zeng, Liu, Xu, He and Guo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SNARE-related genes expression profiles and correlation between gene expression and clinical features in TCGA and CGGA datasets. (A) Heatmap show the different expression levels of 11 SNARE-related genes in TCGA dataset. Up-regulation is shown in red and downregulation is in blue. ***p < 0.001. (B) Violin plot shows the expression of SNARE-related genes in normal tissue and gliomas. (C) Box plot shows SNAP25 expression in different glioma grades in CGGA database. (D) Hazard ratio values of the eleven selected genes. (E, F) Kaplan-Meier survival analysis for glioma patients with low and high risk scores in TCGA and CGGA datasets. Kaplan-Meier survival curve for glioma patients with a high risk score (red line) and a low risk score (blue line). (G) Representative images of SNAP25 expression from glioma tissues and nontumor tissues by ISH assays.