Fig. 5.

The tail length-dependent changes in the Hill coefficient and the potency (EC₅₀) of a capsaicin dose response for mTRPV1. A long hydrophobic and flexible carbon chain serves as a tail of capsaicin. Both the capsaicin potency and the Hill coefficient increase with the increased tail length but have a sharp alteration when the n is five in (CHx)n. The long tail favors the swapping vanilloid bridge via the side chains between the anchor T671 on S6 and F544 on S4. Data were generated from the published article [5].