Figure 4.

Pathway topology analysis completed by entering a list of significant metabolites found by both VIAVC and paired t-test (Table 3) into the web-based tool MetPA. Each circle on the chart indicates a specific metabolic pathway or biological function as labeled to the left of the chart. The x-axis indicates the pathway impact scores, which represents the magnitude of impact by significant metabolites, as shown by the size of each circle. The y-axis corresponds to the p-values, given as -ln(p), with red circles indicating a lower p-value and yellow a higher p-value. Only pathways with p ≤ 0.06 have been labeled.